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KMID : 1144820200260020101
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대한의생명과학회지
2020 Volume.26 No. 2 p.101 ~ p.108
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Protective Effect of Mulberry Leaf and Yacon Extract Induced Hyperlipidemia in Obese Rats
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Lim Yong
Oh Ji-Hye
Park Un-Kyu
Huh Man-Kyu
Hwang Seock-Yeon
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Abstract
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There has been a lot of interest in medicinal effects for hyperlipidemia from the natural product since the therapy of atherosclerosis has emerged as social concern. Rats were acclimated to the feeding environment for one week and induced to obesity with high fat diet during 4 weeks until their body weight were more than 30% of normal range. To evaluate the effect of hyperlipidemia of mulberry leaf of Morus alba and yacon tuber of Smallanthus sonchifolia extracts (MLYT), 1%, 3%, 5% of MLYT were treated to Sprague-Dawley rats. Aspartate transaminase (AST) was significantly increased 26.2% in high fat diet group (G2) compared to normal diet group (G1) (P<0.05). But AST were significantly decreased in high fat diet with 0.5% hydroxycitric acid diet group (G3) and all the MLYT treated groups compared to G2. Total cholesterol, low-density lipoprotein (LDL), triglycerides and phospholipids were observed significant improvements in the MLYT-treated groups (P<0.05). These improvements in liver and feces were further supported by the lipid content. MLYT remarkably suppressed the level of lipid peroxidation caused by high-fat diet in rats. The level of 3-hydroxy- 3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase activity. As a result, the proper combination of mulberry leaves and yacon tuber extract will have a synergistic effect on hyperlipidemia. These results indicate that MLYT could be a candidate for the improvement of hyperlipidemia.
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KEYWORD
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3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA), Hyperlipidemia, Morus alba, Smallanthus sonchifolia, Total cholesterol
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